39 results
Pathophysiology of Hemolytic Anemia
 - Defects in RBC internal contents (thalassemia, hemoglobinopathies, and metabolic defects)
 -
Pathophysiology ... - Defects in RBC ... - Defects in RBC ... environment #Pathophysiology ... Hemolytic #Anemia #hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
Decreased RBC ... Anemia of Chronic Disease ... Infiltration Increased RBC ... Thalassemia • RBC ... Disorder • RBC
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell (RBC ... Morphology Microcytic RBC ... sometimes) Macrocytic RBC ... Bite Cell RBC: G6PD ... Target Cell RBC
Pathologic Red Blood Cell (RBC) Morphologies and Associated Diseases

Acanthocyte (spur cell),  
Basophilic stippling, 
Bite cell,
Red Blood Cell (RBC ... and Associated Diseases ... cell, Other RBC ... Howell-Jolly bodies #RBC ... Microscopy #Pathology #Hematology
Sickle Cell Disease - Pathophysiology of disease and complications 

Due to the deformed shape, HbS induces
- Pathophysiology ... shape, HbS induces RBC ... This leads to RBC ... #Pathophysiology ... Complications #Hematology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
2) External (RBC ... , Drugs, Liver Disease ... 3) Internal (RBC ... Electrolytes: Wilson's disease ... Differential #Diagnosis #hematology
Common RBC Inclusions and Associations
 • Howell Jolly Bodies: Hyposplenism, Asplenism, Severe hemolytic anemia
 • Heinz
Common RBC Inclusions ... : Hemoglobin H disease ... Sickle cell, MDS #RBC ... Bodies #diagnosis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Consider sickle cell disease ... , Hemoglobin H disease ... hypertension • Unusual RBC ... acanthocytes - Consider RBC ... Algorithm #workup #hematology
Red Blood Cell (RBC) Morphology Atlas
 • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell (RBC ... anemia, Liver diseases ... , Liver diseases ... coagulopathy (DIC) #RBC ... #differential #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Neutrophils - Low RBC ... • Pancreatic Disease ... Pernicious Anemia RBCs ... • Liver Disease ... Algorithm #Causes #Hematology