356 results
Oral anticoagulant dosing and bridging for VTE

- Dr. Joseph Shatzel @Clotmaster 

#VTE #DOAC #Bridging #Dosing #Oral
Oral anticoagulant ... Bridging #Dosing #Oral ... Anticoagulation #Dabigatran #Apixaban ... #Rivaroxaban #Edoxaban
NOAC / DOAC Pharmacology and Prescribing Cheat Sheet
Novel (or Direct) Oral Anti-Coagulants
 • Rivaroxaban
 • Apixaban
Novel (or Direct) Oral ... Anti-Coagulants • Rivaroxaban ... • Apixaban ... management #Direct #Oral
Oral Anticoagulation Management Cheat Sheet: Warfarin, Apixaban, Dabigatran, Rivaroxaban
 - Mechanism of Action
 - Routine Blood
Oral Anticoagulation ... Sheet: Warfarin, Apixaban ... , Dabigatran, Rivaroxaban ... - Resume #Oral
Xa Inhibitors - Apixaban and Rivaroxaban 
Oral Xa inhibitors are recommended by CHEST as first-line for
Xa Inhibitors - Apixaban ... and Rivaroxaban ... Oral Xa inhibitors ... and rivaroxaban ... #Rivaroxaban #Dosing
Choice of anticoagulant for treatment of pulmonary embolism
 • Malignancy - LMWH
 • To avoid parenteral
parenteral therapy - Rivaroxaban ... ; apixaban • Once ... a day oral therapy ... - Rivaroxaban; ... Gl bleed - VKA, apixaban
Pharmacokinetic Characteristics and Primary Routes of Clearance of Oral Anticoagulant Agents

Warfarin - 100% Hepatic, 0% Renal
Apixaban
of Clearance of Oral ... Hepatic, 0% Renal Apixaban ... Hepatic, 50% Renal Rivaroxaban ... Pharmacology #Clearance #oral
Heparin, Fondaparinux, and Novel Oral Anticoagulants - Pathophysiology

Anticoagulation with parenteral (intravenous or subcutaneous) and oral anticoagulants
Fondaparinux, and Novel Oral ... anticoagulant (e.g. rivaroxaban ... - Rivaroxaban ... DOAC #Dabigatran #Apixaban ... #Rivaroxaban #Fondaparinux
DOAC Reversal
Emergency surgery or urgent procedure
Stop anticoagulant treatment; volume resuscitation and transfusion as needed
Antidotes:
 • Apixaban,
Antidotes: • Apixaban ... , Edoxaban or Rivaroxaban ... Reversal #NOAC #Oral
Perioperative Management of DOACs
Problem:
 ✖ Each year approximately 250,000 patients on chronic anticoagulation in North America
direct acting oral ... inhibitor) • Apixaban ... , Edoxaban, Rivaroxaban
Warfarin and DOAC Pharmacology
Warfarin - Dabigatran - Rivaroxaban - Apixaban - Edoxaban
Target - Prodrug - Bioavailability
- Dabigatran - Rivaroxaban ... - Apixaban - Edoxaban ... table #dabigatran #rivaroxaban ... #apixaban #edoxaban