352 results
Oral anticoagulant dosing and bridging for VTE

- Dr. Joseph Shatzel @Clotmaster 

#VTE #DOAC #Bridging #Dosing #Oral
Oral anticoagulant ... Bridging #Dosing #Oral ... Dabigatran #Apixaban #Rivaroxaban ... #Edoxaban #Loading
Pharmacokinetic Characteristics and Primary Routes of Clearance of Oral Anticoagulant Agents

Warfarin - 100% Hepatic, 0% Renal
Apixaban
of Clearance of Oral ... Hepatic, 80% Renal Edoxaban ... Hepatic, 50% Renal Rivaroxaban ... Pharmacology #Clearance #oral
Choice of anticoagulant for treatment of pulmonary embolism
 • Malignancy - LMWH
 • To avoid parenteral
parenteral therapy - Rivaroxaban ... • Once a day oral ... therapy - Rivaroxaban ... ; edoxaban; VKA
Xa Inhibitors - Apixaban and Rivaroxaban 
Oral Xa inhibitors are recommended by CHEST as first-line for
- Apixaban and Rivaroxaban ... Oral Xa inhibitors ... indications and edoxaban ... for apixaban and rivaroxaban ... XaInhibitors #Apixaban #Rivaroxaban
Patient risk stratification algorithm for the treatment of cancer-associated thrombosis.

Currently, edoxaban and rivaroxaban are the only
Currently, edoxaban ... and rivaroxaban ... direct-acting oral ... being stronger for edoxaban ... direct-acting oral
DOAC Reversal
Emergency surgery or urgent procedure
Stop anticoagulant treatment; volume resuscitation and transfusion as needed
Antidotes:
 • Apixaban,
: • Apixaban, Edoxaban ... or Rivaroxaban ... Reversal #NOAC #Oral
Perioperative Management of DOACs
Problem:
 ✖ Each year approximately 250,000 patients on chronic anticoagulation in North America
direct acting oral ... ) • Apixaban, Edoxaban ... , Rivaroxaban (anti-XA
Warfarin and DOAC Pharmacology
Warfarin - Dabigatran - Rivaroxaban - Apixaban - Edoxaban
Target - Prodrug - Bioavailability
- Dabigatran - Rivaroxaban ... - Apixaban - Edoxaban ... table #dabigatran #rivaroxaban ... #apixaban #edoxaban
DOAC Cheat Sheet
 • Apixaban, Dabigatran, Edoxaban, Rivaroxaban
 • Renal Dosing
 • Common Drug interactions
 •
Apixaban, Dabigatran, Edoxaban ... , Rivaroxaban
Switching Between Anticoagulants and DOACs
VKA, Dabigatran, Rivaroxaban, Apixaban, Edoxaban, Betrixaban, DOAC, Parenteral anticoagulant

DOI: 10.1161/JAHA.120.017559

#Anticoagulants #DOACs #anticoagulation
VKA, Dabigatran, Rivaroxaban ... , Apixaban, Edoxaban