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management oncology hepatology algorithm joint arthritis msk alkaline alp approach blood classification disorders hemophagocytic hlh hodgkins lymphohistiocytosis lymphoma phosphatase product
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Diagnosis and Workup ... pylori test (GI symptoms ... candidate) - Bone ... #Diagnosis #Causes ... #Workup #hematology
Causes of Bone/Joint Pain in Sickle Cell Disease Vaso-occlusive pain: • Mechanism: ischemic pain • Can present
Causes of Bone/Joint ... • Differentiate ... #Disease #differential ... #diagnosis #causes ... #hematology
Hemolysis - Diagnostic Algorithm and Causes Increased red cell production: • Increased Reticulocytosis/polychromasia • Erythroid
Hemolysis - Diagnostic ... hyperplasia of bone ... Anemia #Algorithm #Differential ... #Causes #Workup ... #Hematology #Diagnosis
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
Diagnosis Algorithm ... • Liver (80%) ... Intestine - Other causes ... symptoms - Pain ... #hepatology
Aortitis - Diagnosis and Workup Clinical History: - Fever, weight loss, deterioration of general health - Aortic
Aortitis - Diagnosis ... regurgitation - Pain ... hypertension) - Symptoms ... Nivolumab, GM-CSF ... #Workup #Differential
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
evaluation or workup ... for specific symptoms ... 1,500 cells/µL Workup ... Disorders #Algorithm #Differential ... #diagnosis #hematology
Fever of Unknown Origin (FUO) - Further Workup • CNS symptoms? Get an LP and imaging
FUO) - Further Workup ... • CNS symptoms ... values supporting hematologic ... Bone marrow biopsy ... #diagnosis
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... Drug induced - Bone ... deficiency • Liver ... #Diagnosis #hematology ... #rheumatology #
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
synthesized in: liver ... Most cases diagnosed ... mineralization Symptoms ... Phosphatase: • Other causes ... Hyophosphatasia #hepatology
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
postpartum): • Initial symptoms ... = nonspecific (nausea ... vomiting, abdominal pain ... infiltration) Differential ... Diagnosis: Viral
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