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diagnosis management allergy differential dili hepatology hypersensitivity injury liver reactions shock table allergic cold criticalcare definitions drug druginduced dry gammopathy
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
Mediator: IgM + IgG ... purpura, Heparin induced ... anemia, Penicillin-induced ... Immunological Mediator: IgG ... #Classification
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
cross-linking of lgE induces ... II - IgG or IgM ... IgG can also mediate ... Type Ill - IgG and ... #Classification
Subtypes of Serum Proteins Pre-albumin (Transthyretin) Albumin Globulins • Alpha-1: Alpha-1 antitrypsin, Serum amyloid A, Ceruloplasmin, Corticosteroid-binding globulin (Transcortin),
• Gamma: IgM, IgG ... Proteins #Subtypes #algorithm ... #classification ... #Types #hematology
Shock Types - Classification State of cellular and tissue hypoxia due to: reduced oxygen delivery, increased oxygen
Shock Types - Classification ... - Most common type ... valvular rupture, dissection ... water #Shock #Classification ... #types #diagnosis
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Idiosyncratic Drug-induced ... (DILI) DILI Types ... - predictable, dose ... less consistent dose ... gastroenterology #algorithm
Shock Classification Shock Definition: State of cellular and tissue hypoxia due to: reduced oxygen delivery, increased oxygen
Shock Classification ... • Most common type ... valvular rupture, dissection ... water #Shock #Classification ... #Types #diagnosis
IGG-4 RELATED DISEASE WHAT? • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
• Pancreas: Type ... mass: "sausage shaped ... complement • Classification ... Rituximab: 1 g IV x2 doses ... : 300 mg IV x2 doses
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Drug Induced Liver ... Stepwise Diagnosis Algorithm ... information (e.g. dose ... Autoantibody titres, ↑ IgG ... Injury #Diagnosis #Algorithm
Monoclonal Gammopathy of Renal Significance (MGRS) MGRS • MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
disorder that does ... Why Does MGRS Matter ... • Hematuria • Reduced ... guide subtype classification ... vasculitis Types
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