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Renal Involvement in Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#Renal #diseases #SLE #Systemic #Lupus #Erythematosus #venn #nephrology
Renal #diseases #SLE ... #Systemic #Lupus ... Erythematosus #venn #nephrology ... #nephritis #classification ... #types #rheumatology
Lupus Nephritis Primer
Class I - Minimal Mesangial
Class II - Mesangial Proliferative
Class Ill - Focal Proliferative
Class IV
Lupus Nephritis ... #Nephritis #SLE ... #Classification ... differential #diagnosis #management ... #nephrology
Classification of Diabetes Insipidus

Central or neurogenic diabetes insipidus:
 - Congenital - Structural malformations affecting the hypothalamus
Classification of ... causes (e.g., hypokalemia ... , hypercalcemia) ... #Classification ... #Types #Nephrology
Management of Lupus Nephritis
Lupus nephritis (LN) in 10 to 40% of SLE
Hallmark = proteinuria 20.5 g/g
Management of Lupus ... in 10 to 40% of SLE ... severity (ISN/RPS classification ... by 12 months Classification ... #rheumatology #nephrology
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
Hyperkalemia - Differential ... (Uncontrolled diabetes ... insufficiency/Failure • SLE ... • Type IV RTA ... potassium #high #nephrology
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
Hyperkalemia - Differential ... (Uncontrolled diabetes ... insufficiency/Failure • SLE ... • Type IV RTA ... potassium #high #nephrology
Causes of Hyperkalemia
l. Pseudohyperkalemia
  A Cellular efflux; thrombocytosis, erythrocytosis, leukocytosis, in vitro hemolysis
  B.
diseases: syßtemic lupus ... erythematosus (SLE ... Diabetes, diabetic ... Pseudohypoaldosteronism type ... High #Potassium #Classification
Hyperkalemia - Diagnosis and Management - GrepMed Handbook

S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
and Management ... Aldosterone, RTA Type ... and Elimination (see ... - IV loop diuretic ... Treatment #potassium #nephrology
Continuous Renal Replacement Therapy (CRRT) - Overview
Types of CRRT
 • CVVHD - Continuous Veno-Venous hemodialysis -
CRRT) - Overview Types ... electrolytes (essentially hyperkalemia ... volume overload; diuretic ... #Indications #Nephrology ... #Management