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diagnosis hematology differential oncology erythematosus systemic vasculitis classification clinical cutaneous leukemia management activation algorithm antiphospholipid apls chronic cll cryoglobulinemia cryoglobulins
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Malar rash • SLE ... Antiphospholipid-antibody syndrome ... lesions • Discoid lupus ... Sarcoidosis #dermatology ... differential #diagnosis #rheumatology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... Associated with skin ... block • Sjogren syndrome ... #Systemic #Lupus ... Summary #diagnosis #rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Features of Systemic Lupus ... (SLE) General: ... Sjögrens (15%) Skin ... Demyelinating syndromes ... symptoms #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... 3rd Decade Skin ... Non-autoimmune rheumatologic ... Seizures • Strokes Skin ... Erythematosus #Diagnosis #Rheumatology
Vasculitis Involving the Skin - Differential Diagnosis Framework Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis Secondary: CTD: SLE, RA
Involving the Skin ... Secondary: CTD: SLE ... Vasculitis Skin ... Disease • Cogan syndrome ... #dermatology #rheumatology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
purple, hemorrhagic skin ... Associated - SLE ... Differential #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
disease • Systemic lupus ... SJIA], systemic lupus ... erythematosus [SLE ... Diagnosis #Management #Hematology ... #Rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
- Purpura - Skin ... reticularis & skin ... (e.g. systemic lupus ... erythematosus (SLE ... classification #rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Alpha & Mu) Skin ... capillary leak syndrome ... thrombosis+Pulm HTN+skin ... to cold IgG • Lupus ... Paraproteinemias #Hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
inflammation Others: • Lupus ... • Cogan Syndrome ... such as systemic lupus ... vasculitis, and SLE ... differential #diagnosis #rheumatology
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