12 results
Causes of Thrombocytopenia - Differential Diagnosis Framework
Decreased Production:
 - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
Causes of Thrombocytopenia ... Differential Diagnosis Framework ... folate def - Bone ... - Autoimmune: SLE ... #hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Differential Diagnosis Framework ... : • Vascular occlusion ... Drug induced - Bone ... Splenomegaly - CTD (SLE ... Associated - SLE
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... Criteria for Systemic Lupus ... domain: Leukopenia, Thrombocytopenia ... #EULARACR #Classification ... #Criteria #SLE
Causes of Bone/Joint Pain in Sickle Cell Disease
Vaso-occlusive pain:
 • Mechanism: ischemic pain
 • Can present
Causes of Bone/Joint ... Disease Vaso-occlusive ... dz difficult to see ... Differentiate from vaso-occlusive ... diagnosis #causes #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Causes of Thrombocytopenia ... test, ANA (e.g., SLE ... candidate) - Bone ... patients with thrombocytopenia ... Causes #Workup #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... microangiopathy: Thrombotic thrombocytopenic ... usually IgG) (e.g. lupus ... differential #diagnosis #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
blood smear or on bone ... infiltrates (anemia, thrombocytopenia ... lymphocytic lymphoma (SLL ... Lymphocytic Lymphoma (SLL ... #Leukemia #Hematology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
disease • Systemic lupus ... SJIA], systemic lupus ... erythematosus [SLE ... leukopenia, anemia, and thrombocytopenia ... Diagnosis #Management #Hematology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
non-Hodgkin lymphoma SLL ... Neutropenia, anemia, thrombocytopenia ... Warm AIHA • Bone ... lymphoma • Marginal zone ... workup #oncology #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Differential Diagnosis Framework ... such as systemic lupus ... reactions, and vaso-occlusive ... vasculitis, and SLE ... #rheumatology #classification