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diagnosis differential rheumatology hematology oncology manifestations signs clinical compared comparison complications cryoglobulinemia cryoglobulins damage dermpath disease erythemas erythematosus exposure hypertension
Dermatological semiology of Cutaneous Vasculitis Clinicopathologic correlations • Purpura, papules, pustules, necrosis: involvement of small vessels
Dermatological semiology of Cutaneous ... Identification of causes ... the context of cutaneous ... disease (10%) : SLE ... #dermatology #semiology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
: • Vascular occlusion ... Drug induced - Bone ... Splenomegaly - CTD (SLE ... Associated - SLE ... #nonpalpable #dermatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... such as systemic lupus ... reactions, and vaso-occlusive ... , and SLE) • Urinalysis ... #rheumatology #classification
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... response -> Subacute cutaneous ... hair follicles -> causes ... Livedo Reticularis, Vasculitis ... #SLE #Mucocutaneous
Causes of Bone/Joint Pain in Sickle Cell Disease Vaso-occlusive pain: • Mechanism: ischemic pain • Can present
Causes of Bone/Joint ... Disease Vaso-occlusive ... dz difficult to see ... differential #diagnosis #causes ... #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Skin Disease Classification ... : • Acute cutaneous ... ANCA-associated vasculitis ... Vasculitis: •
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... Henoch-Schönlein purpura) • Cutaneous ... (e.g. systemic lupus ... diagnosis #types #classification
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
diseases, such as SLE ... reactions, and vaso-occlusive ... Strong sign of cutaneous ... tract, and often causes ... (lower legs), cutaneous
Clinical Classification of Pulmonary Hypertension 1. Pulmonary arterial hypertension from pulmonary vasculopathy Idiopathic pulmonary arterial hypertension Heritable gene mutations
Clinical Classification ... mutations - BMPR2 (bone ... Pulmonary veno-occlusive ... neurofibromatosis, vasculitis ... #Differential #Causes
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
gangrenosum • Cutaneous ... Autoimmunity: • -MM/WM: Vasculitis ... Hypergammaglobulinemic macular Vasculitis ... to cold IgG • Lupus ... Paraproteinemias #Hematology
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