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diagnosis differential rheumatology hematology classification hairloss algorithm arterial complications cryofibrinogenemia cryoglobulinemia cryoglobulins diffuse embolism erythematosus focal hair joint loss manifestations
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... hair follicles -> causes ... inflammation on skin ... Livedo Reticularis, Vasculitis ... Manifestations #pathophysiology
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Hypersensitivity vasculitis ... Antiphospholipid-antibody syndrome ... • Vasculitis ... lesions • Discoid lupus ... Sarcoidosis #dermatology
Hair Loss (Alopecia) - General (Diffuse and Focal) Differential Diagnosis Algorithm DIFFUSE Scarring - Irreversible-biopsy required • Lupus
• Loose anagen syndrome ... - Secondary to Skin ... • Discoid lupus ... #dermatology #Differential ... Diagnosis #Algorithm #causes
Allopecia - Differential Diagnosis Framework for Hair Loss Localized / Focal Hair Loss Pattern: • Scarring Alopecia:
Capitis - Skin ... Disease: Discoid lupus ... : Lupus erythematosus ... , Loose anagen syndrome ... Differential #Diagnosis #dermatology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
purple, hemorrhagic skin ... : • Vascular occlusion ... Kasabach-Merritt syndrome ... Associated - SLE ... #nonpalpable #dermatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... 3rd Decade Skin ... and permanent alopecia ... Seizures • Strokes Skin ... • Nonscarring alopecia
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... inflammation Others: • Lupus ... such as systemic lupus ... reactions, and vaso-occlusive ... , and SLE) • Urinalysis
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... - Purpura - Skin ... Cryoglobulins Cause ... reticularis & skin ... (e.g. systemic lupus
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
) is a skin condition ... Causes: - Idiopathic ... Leukocytoclastic vasculitis ... - Lupus - Leukemia ... #diagnosis #dermatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
diseases, such as SLE ... reactions, and vaso-occlusive ... tract, and often causes ... • Behcet syndrome ... • Cogan syndrome
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