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diagnosis management differential hematology oncology vasculitis anca anemia antibodies antibody antineutrophil antinuclear antinxp2 antinxp2dm aplastic classification clinical cutaneous dermatomyositis diseases
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Testing Algorithm ... (common causes ... glucocorticoid treatment ... symptoms (eg, skin ... Differential #diagnosis #hematology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Antinuclear (ANA ... severe disease & renal ... Associated with skin ... severe disease Treatment ... Summary #diagnosis #rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
) • Systemic lupus ... in drug-induced SLE ... + 60% • Eosinophilic ... Jcortesizaguirr #ANA ... antibodies #diagnosis #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
• EGPA: - Eosinophilia ... causes arthritis ... such as systemic lupus ... SLE) • Urinalysis ... differential #diagnosis #rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Alpha & Mu) Skin ... to cold IgG • Lupus ... Episodic angioedema+eosinophilia ... , retinal, DVT, ... Paraproteinemias #Hematology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
renal abnormalities ... diseases, such as SLE ... Polyangiitis): • Eosinophilia ... causes arthritis ... Differential #Diagnosis #Rheumatology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Headaches • Pale skin ... petechiae Causes ... - Hepatitis, eosinophilic ... aplastic anemia Treatment ... Anemia #oncology #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... • (Peripheral eosinophilia ... lymphocytic lymphoma (SLL ... CLL -> Invade Skin ... #Leukemia #Hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Lacrimal swelling • Skin ... overlaps with RA, SLE ... Hypocomplementemia • Can cause ... Adenocarcinoma Treatment ... Sjogrens #Syndrome #Rheumatology
Cutaneous Mucormycosis Eschar 30 M HIV cd4 10 VL 30k traumatic injury of arm few months ago
started as nodule and ... malnutrition, HIV, SLE ... Mucormycosis #Eschar #dermatology ... #skin #clinical ... #photo
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