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diagnosis rheumatology syndrome classification management acute ana anca antineutrophil antinuclear antinxp2 antinxp2dm clinical cryoglobulinemia cryoglobulins cutaneous dermatomyositis differential diseases erythematosus
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
) • Systemic lupus ... in drug-induced SLE ... ) • Systemic sclerosis ... ANCA-Associated Vasculitis ... vasculitis - MPO
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... inflammation Others: • Lupus ... lupus erythematosus ... C-ANCA) pattern: antibodies ... , and SLE) • Urinalysis
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... - Purpura - Skin ... Cryoglobulins Cause ... Antineutrophil cytoplasmic antibody ... lupus erythematosus
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... 3rd Decade Skin ... Seizures • Strokes Skin ... 1, SCL-70, RNP antibodies ... #Systemic #Lupus
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... Hypocomplementemia • Can cause ... ) • Cutaneous vasculitis ... Vasculitis: • ... Adenocarcinoma Treatment
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
Causes: - Idiopathic ... Leukocytoclastic vasculitis ... ’s syndrome - Lupus ... Treatment: - Systemic ... Syndrome #diagnosis #dermatology
Acute Retroviral Syndrome Acute Retroviral Syndrome is the symptomatic presentation of acute human immunodeficiency virus infection •
sweats (28%) • Skin ... Central nervous system ... • New onset SLE ... Detects both HIV antibody ... test) Treatment
Cutaneous Mucormycosis Eschar 30 M HIV cd4 10 VL 30k traumatic injury of arm few months ago
malnutrition, HIV, SLE ... wide excision & systemic ... Mucormycosis #Eschar #dermatology ... #skin #clinical ... #photo
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
• Antibodies targeting ... Muscle atrophy may cause ... levels • NXP-2 antibody ... positive patients Treatment ... #rheumatology #dermatology
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