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diagnosis rheumatology differential causes erythematosus hematology symptoms vasculitis activation algorithm chronic cll cryoglobulinemia cryoglobulins high hyperkalemia leukemia lymphocytic macrophage management
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings • Primary Sjögren's is a solitary process whereas secondary Sjögren's
process whereas secondary ... diseases • In secondary ... (PBC), or with systemic ... lupus erythematosus ... (SLE) Signs /
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Lupus (SLE) General ... Demyelinating syndromes ... Abdominal pain (20%) Renal ... #SLE #systemic ... erythematosus #signs
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Nail Disorders secondary ... Abnormality • SLE ... discoloration) • Chronic renal ... • Nephrotic syndrome ... #Secondary #dermatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Classified among the secondary ... lupus erythematosus ... lupus erythematosus ... [SLE], AOSD) • ... Diagnosis #Management #Hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Skin Disease Classification ... Neuropsychiatric systemic ... APLA/LAC: • Renal ... #Systemic #Lupus
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... Type III Often Secondary ... lupus erythematosus ... (SLE), rheumatoid ... diagnosis #types #classification
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
inflammation Others: • Lupus ... lupus erythematosus ... purpura: strong sign ... vasculitis, and SLE ... #rheumatology #classification
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
rendering the immune system ... non-Hodgkin lymphoma SLL ... Physical Exam/Signs ... ’s CLL Scoring system ... Leukemia #diagnosis #workup
Causes of Hyperkalemia l. Pseudohyperkalemia A Cellular efflux; thrombocytosis, erythrocytosis, leukocytosis, in vitro hemolysis B.
lupus erythematosus ... (SLE), sickle cell ... Tubulointerstitial diseases: SLE ... antiphospholipid syndrome ... High #Potassium #Classification
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