10 results
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings
• Primary Sjögren's is a solitary process whereas secondary Sjögren's
process whereas secondary ... diseases • In secondary ... (PBC), or with systemic ... lupus erythematosus ... (SLE) Signs /
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes
== Primary Skin Lesions ==
Macules /
Pruritus - Generalized ... BUN: • Chronic renal ... Myelodisplastic syndrome ... #primary #secondary ... #dermatology #Differential
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Lupus (SLE) General ... Butterfly rash, Vasculitis ... Demyelinating syndromes ... #SLE #systemic ... erythematosus #signs
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm

Blood Glucose:
 • Diabetes Mellitus
Liver Function Tests/Enzymes:
Pruritus - No Primary ... BUN: • Chronic renal ... Myelodisplastic syndrome ... #secondary #systemic ... #generalized #dermatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
inflammation Others: • Lupus ... • Cogan Syndrome ... lupus erythematosus ... purpura: strong sign ... , and SLE) • Urinalysis
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... ANCA-associated vasculitis ... the context of primary ... APLA/LAC: • Renal ... #Systemic #Lupus
Causes of Secondary Hypertension - Workup and Differential Diagnosis
Approach (when evaluation should be done):
1. Severe or
Causes of Secondary ... Hypertension - Workup ... bruit or signs ... Coarctation of aorta, Vasculitis ... Hypothyroidism, Primary
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
pulmonary and renal ... diseases, such as SLE ... purpura: Strong sign ... with GCA or as primary ... Rash, arthritis Primary
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
Primary (essential ... malignancies, vasculitis ... processes: • Systemic ... • Painful or pruritic ... thrombi including retinal
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
Vaginal dryness • Primary ... other diseases • Secondary ... overlaps with RA, SLE ... ) • Cutaneous vasculitis ... Vasculitis: •