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diagnosis rheumatology differential monoclonal oncology erythematosus gammopathy systemic anorexianervosa arthritis chronic classification cll gap globulin leukemia lymphocytic paraproteinemias pathophysiology protein
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Abdominal pain (20%) Renal ... ) Blood (75%): Anemia ... erythematosus #signs ... #symptoms #diagnosis ... #rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
(-) hemolytic anemia ... to cold IgG • Lupus ... vascular beds-renal ... , retinal, DVT, ... Paraproteinemias #Hematology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
No evidence of anemia ... constitutional symptoms ... hyperCalcemia, Renal ... insufficiency, Anemia ... #Significance #hematology
Complications of Monoclonal Gammopathy of Undetermined Significance (MGUS) Fracture, Osteoporosis - Increased osteoclast activity and bone resorption
Complications of ... Significance (MGUS ... treatment of infective symptoms ... ; vaccinations Renal ... #diagnosis #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... APLA/LAC: • Renal ... vein thrombosis Hematologic ... lymphopenia, low PLT • Anemia ... : • Symptoms limited
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... Physical Exam/Signs ... • Neutropenia, anemia ... Leukemia #diagnosis #workup ... #oncology #hematology
Rheumatoid Arthritis - Signs and Symptoms • Ocular: Keratoconjunctivitis sicca, Episcleritis, Scleritis, Scleromalacia perforans • Pulmonary:
and Symptoms • ... Airways disease, Complications ... Pericarditis • Renal ... Hematological: Anemia ... #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
pulmonary and renal ... Presentation - Systemic Symptoms ... purpura: strong sign ... vasculitis, and SLE ... • Urinalysis (Renal
Anorexia Nervosa: Complications CARDIAC ABNORMALITIES - Functional: Low BP, Sinus bradycardia, prolonged QT interval - Structural: Reduced
fasting/weight loss RENAL ... and memory loss HEMATOLOGIC ... lymphocytosis, mild anemia ... risk of fracture DERMATOLOGIC ... #symptoms #psychiatry
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... Gammopathy Include: • MGUS ... cancers, HCC, renal ... gastric tumors • Hematology ... differential #diagnosis #hematology
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