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rheumatology erythematosus lupus management ana dermatology differential disease signs symptoms workup activation antibodies arthritis autoantibodies behcet causes chronic cll cutaneous
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
and Systemic lupus ... is clinically suspected ... overlap syndromes ... erythematosus #diagnosis ... table #ANA
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Abnormality • SLE ... Iron deficiency anemia ... • Nephrotic syndrome ... #Differential #Diagnosis ... #Algorithm #causes
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... likely it will be clinically ... ), Sjogren's Syndrome ... Arthritis, Sjögren Syndrome ... #diagnosis #differential
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... Demyelinating syndromes ... ) Blood (75%): Anemia ... signs #symptoms #diagnosis ... #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Clinical Presentation ... erythematosus [SLE ... with leukopenia, anemia ... #Diagnosis #Management ... #Hematology #Rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... ) Suspect: Clinical ... Differential Diagnosis ... Clinical Features ... lymphopenia, low PLT • Anemia
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Systemic disease ... Venous disease (SVC ... (Clinical Dx). ... Oral aphthae : SLE ... • Arthritis: SLE
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... Diagnosis: • Dry ... ab • RF • Antinuclear ... salivary ducts Clinical ... Nephrogenic DI Hematologic
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
rendering the immune system ... Orange or Hep C Clinical ... ’s CLL Scoring system ... • Neutropenia, anemia ... workup #oncology #hematology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
affected joint • Systemic ... ) - Antinuclear ... the presence of anemia ... (to support a diagnosis ... ANA and RF (if clinical
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