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Vasopressors Demystified

Shock comes in many flavors and so do vasopressors. Here’s a OnePager summarizing my approach
Vasopressors Demystified ... Shock comes ... #Basics #CriticalCare ... #Management #Pharmacology ... #Comparison #Inotropes
Vasopressors and Inotropes - Pharmacology Summary
Vasopressors
Phenylephrine (alpha-1)
 • Increases BP, SVR
 • Risk of reflex bradycardia
first agent in shock ... line in septic shock ... Dose dependent receptor ... Pharmacology #Summary #management ... #medications
Vasopressors and Inotropes
 • Norepinephrine - Levophed - "Levo" - Generally thought of as the first
Vasopressors and ... #Inotropes #management ... #criticalcare # ... summary #comparison ... #pharmacology #indications
Shock - Differential Diagnosis Framework
 - MAP <65. SBP <90, drop in SBP > 40
 -
Failure, Toxins/Medications ... Treatment Goals ... Differential #Diagnosis #criticalcare ... #algorithm #treatment ... #management
Pressors and Inotropes

Norepinephrine
 • alpha1 > beta 1
 • Increase SVR > Inotropy
Vasopressin
 • V1
 •
1 • Increase SVR ... 1 • Increase SVR ... Pressors #Inotropes #criticalcare ... #pharmacology #comparison ... #shock #management
Shock - Diagnosis and Management Summary
 • Hypotension: SBP<90, SBP drop >40, MAP<65 (Normotension, HTN possible
and Management ... Prepare • Full Set ... Neurogenic >> Vasopressors ... #Summary #criticalcare ... #treatment #workup
Sepsis - Diagnosis and Management
Life-threatening organ dysfunction caused by a dysregulated host response to infection
SEPTIC SHOCK
infection SEPTIC SHOCK ... Patients w/ septic shock ... recognition and treatment ... resuscitation 3 Vasopressor ... #QSOFA #SIRS #criticalcare
Systemic Inflammatory Response Syndrome (SIRS)
•	Non-specific (infections vs non-infectious)
•	≥2 of the following:
o	Temp >38°C or <36°C
o	HR >90 bpm
o	RR
Septic Shock • ... >2 mmol/L Management ... recognition & treatment ... glycemic control, DVT ... #sepsis #sirs #shock
Management of SIADH
Treat underlying cause:
 • Causes can include pain, primary lung pathology, post-operative phenomenon, medications,
Management of SIADH ... post-operative phenomenon, medications ... bolus of 0.9% NS Vasopressor ... receptor antagonists ... hyponatremia #nephrology #treatment
Approach to Undifferentiated Shock - OnePager Summary
Shock occurs when there is inadequate blood flow (CO) &
Undifferentiated Shock ... essential to determine treatment ... Pipes Problem (↓ SVR ... thyrotoxicosis), Medications ... guyton #curves #criticalcare