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diagnosis oncology hemolysis management workup causes chronic cll disease hemolytic leukemia agglutinin behcet classification disorders extravascular hemeonc hodgkins intravascular lymphoma
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
• Peripheral smear ... immunophenotype Clinical ... 5) Symptoms of anemia ... marrow failure with anemia ... Leukemia #oncology #hematology
Differential diagnosis of schistocytes / fragmentation hemolysis: • Thrombotic microangiopathies (TMA) - TTP
Differential diagnosis ... hemolysis: • Thrombotic ... hemolytic-uremic syndrome (ST-HUS ... macroangiopathic hemolytic anemia ... #diagnosis #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Autoimmune: Warm AIHA, Cold ... Defects: Sickle cell anemia ... Peripheral Blood Smear ... #Diagnosis #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
syndrome - Thrombotic ... (e.g. primary cold ... Extravascular #Causes #differential ... #diagnosis #hematology ... #anemia
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... Orange or Hep C Clinical ... • Peripheral smear ... • Neutropenia, anemia ... workup #oncology #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Viral Infection Clinical ... • Symptoms of anemia ... IgM) • Blood smear ... younger pts) Differential ... #hematology #diagnosis
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Platelet Disorders - Differential ... practices that could ... peripheral blood smear ... changes), high MCV anemia ... Causes #Workup #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
Evaluation for Thrombotic ... result in severe anemia ... Peripheral blood smear ... WBC count and differential ... Diagnosis #Workup #Hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
(-) hemolytic anemia ... due to cold IgG ... Hyperviscosity (Thrombosis ... Paraproteinemias #Hematology ... #Monoclonal #Differential
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Hodgkin Lymphoma - Clinical ... Weight loss • Anemia ... Immune hemolytic anemia ... Immunohistochemical studies (to differentiate ... classification #hematology
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