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differential algorithm rheumatology management causes oncology clinical photo secondary signs symptoms erythematosus hemolysis lupus pediatrics peds purpura skinrash sle thrombocytopenia
Differential diagnosis of schistocytes / fragmentation hemolysis: • Thrombotic microangiopathies (TMA) - TTP
Differential diagnosis ... : • Thrombotic ... syndrome (ST-HUS ... anemia" • HELLP ... #hematology #hemolysis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... anemia): ... - Thrombotic ... uremic syndrome ... #hematology #anemia
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Myelodysplastic syndrome ... uremic syndrome ... , Thrombotic idiopathic ... Morphology #Atlas #key #diagnosis ... #differential #hematology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Sjögrens (15%) Skin ... Photosensitivity, Butterfly rash ... Demyelinating syndromes ... ) Blood (75%): Anemia ... signs #symptoms #diagnosis
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
deficiency • Fanconi’s anemia ... Wiskott-Aldrich syndrome ... Autoimmune Diseases: • Systemic ... Antibody-mediated hemolysis ... #Hematology
Algorithm for workup of thrombocytopenia based on observation of the peripheral blood film. TTP/HUS indicates thrombotic
/HUS indicates thrombotic ... thrombocytopenic purpura/hemolytic ... uremic syndrome ... thrombocytopenia, Hematology ... 2012, p 193 #Diagnosis
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Alpha & Mu) Skin ... • Coombs (-) hemolytic ... anemia due to cold ... Paraproteinemias #Hematology ... #Differential #Diagnosis
Algorithm for Diagnosis of the Petechial / Purpuric Rash Febrile/Toxic, Palpable: - Meningococcaemia, Disseminated Gonococcal Infection,
Algorithm for Diagnosis ... Petechial / Purpuric Rash ... Fulminans, DIC, Thrombotic ... #Algorithm #Diagnosis ... #Dermatology #Skin
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Generalized Differential Diagnosis ... renal failure/uremia ... Myelodisplastic syndrome ... #generalized #dermatology ... #Differential #Diagnosis
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Joint Pain Rash ... infection Malar rash ... Antiphospholipid-antibody syndrome ... Sarcoidosis #dermatology ... #differential #diagnosis
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