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Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Thrombotic Microangiopathies ... Lupusreference #TMAs #Thrombotic ... Erythematosus #SLE #hematology ... differential #diagnosis ... #causes
Causes of Arterial and Venous Thrombosis - Differential Diagnosis Framework

STRUCTURAL:
 - PFO: paradoxical emboli
 - Popliteal
Causes of Arterial ... - Differential Diagnosis ... artery aneurysm: Causes ... compression and DVT ... #clots #hematology
Recently TEG has emerged as a more integrative approach which explores both clotting factors and cellular
involves monitoring thrombosis ... and thrombolysis ... #Diagnosis #Thromboelastography ... Thromboelastogram #TEG #Interpretation ... #Laboratory #Hematology
Disorders of the Hepatic and Mesenteric Circulation

Platelets in Cirrhosis
Hypercoagulability in Cirrhosis
Bleeding in Cirrhosis
Portal Vein Thrombosis (PVT)
Mesenteric
Cirrhosis Portal Vein Thrombosis ... Vein Thrombosis ... Syndrome (BCS) ... Circulation #Disorders #Hepatology ... Gastroenterology #diagnosis
Thrombotic Microangiopathies - Primary Thrombotic Microangiopathy (TMA) - Differential Diagnosis Table

 • Thrombotic Thrombocytopenic Purpura (TTP)
- Differential Diagnosis ... TableThrombotic ... Toxin-Mediated HUS (ST-HUS ... Microangiopathy #TMA #hematology ... #differential #diagnosis
Causes of Breakthrough/Extension of Thrombosis and Management Algorithm

#Anticoagulation #Breakthrough #Thrombosis #Algorithm #Extension #VTE #DVT #Hematology #Management
Causes of Breakthrough ... Extension #VTE #DVT ... #Hematology #Management ... #Diagnosis #Differential ... #Causes
Differential diagnosis of schistocytes / fragmentation hemolysis:
 • Thrombotic microangiopathies (TMA)
    - TTP
Differential diagnosis ... hemolysis: • Thrombotic ... hemolytic-uremic syndrome ... (ST-HUS) - ... #hematology #hemolysis
Recurrent / Breakthrough DVT During Anticoagulation

Subtherapeutic Anticoagulation
Hypercoagulable State 
 - Antithrombin deficiency 
 - Hypercoagulability ot
/ Breakthrough DVT ... Structural - Pelvic masses ... - May-Thurner syndrome ... Breakthrough #Recurrent #DVT ... anticoagulation #hematology
Ascites Differential Diagnosis Table - Serum Ascites Albumin Gradient (SAAG)

SAAG ≥ 1.1:
 • Cirrhosis
 • Portal
Table - Serum Ascites ... • Portal vein thrombosis ... • Nephrotic syndrome ... #Table #Serum # ... Gradient #SAAG #hepatology
Algorithm for workup of thrombocytopenia based on observation of the peripheral blood film. 
TTP/HUS indicates thrombotic
/HUS indicates thrombotic ... hemolytic uremic syndrome ... thrombocytopenia, Hematology ... 2012, p 193 #Diagnosis