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diagnosis gammopathy management monoclonal algorithm anticoagulation cancer differential doac malignancy vte cell complications cryofibrinogenemia formation hemeonc heparin hit igm induced
Rouleaux formation is common in IgM gammopathy and may be particularly striking Genevieve Crane, MD, PhD@evemariecrane #Rouleaux #formation
IgM #gammopathy #MGUS ... #Clinical #Pathology ... #Hematology #Smear
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Gammopathy of Clinical ... Significance (MGUS ... Monoclonal #Gammopathy #Clinical ... Differential #Diagnosis #hematology ... #oncology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Organomegaly+↑RBC/plt+, ↑thrombosis ... Hyperviscosity (Thrombosis ... beds-renal, retinal, DVT ... Paraproteinemias #Hematology ... Differential #Diagnosis #Oncology
Patient risk stratification algorithm for the treatment of cancer-associated thrombosis. Currently, edoxaban and rivaroxaban are the only
cancer-associated thrombosis ... DVT = deep vein ... thrombosis; PE = ... Anticoagulation #Management #Hematology ... #Oncology
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 Treatment algorithm for VTE in Malignancy (A) Suggested treatment algorithm for symptomatic and incidental DVT or PE
and incidental DVT ... catheter-related thrombosis ... without concomitant DVT ... Anticoagulation #Management #Hematology ... #Oncology
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook Presentation: • Plts ↓50% (nadir
5-10d, venous (DVT ... PE) or arterial thrombosis ... Diagnosis: • Clinical ... non-heparin A/C if clinical ... Management #Treatment #Hematology
Complications of Monoclonal Gammopathy of Undetermined Significance (MGUS) Fracture, Osteoporosis - Increased osteoclast activity and bone resorption
Significance (MGUS ... rituximab (in clinical ... trials) Thrombosis ... high-risk situations #MGUS ... Complications #diagnosis #hematology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
necrosis) - Thrombosis ... (Thrombotic vasculopathy ... Biopsy: Typical pathologic ... Cryofibrinogenemia #diagnosis #rheumatology ... #hematology
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
plasmacytoma) Clinical ... IFE, FLC assay Pathology ... #Plasmacytoma #Oncology ... Diagnosis #Workup #Hematology
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