17 results
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
with cytotoxic T ... cytokines, which activate ... and cytotoxic T ... Hypersensitivity #Types #Classification ... #Pathophysiology
Type IV Hypersensitivity: Pathogenesis and clinical findings
Definition: Unique because it is entirely T-Cell mediated; exposure to
it is entirely T-Cell ... allergen-specific T-Cell ... exposure, because T-Cell ... activate macrophages ... Allergy #Immunology #pathophysiology
Inflammatory mechanism of asthma. 
Airway epithelial cells exposed to activation stimuli, including allergens, viruses, and irritants,
Airway epithelial cells ... antigens and thereby activate ... naive CD4 T cells ... These T cells then ... #asthma #pathophysiology
Inflammatory Cascade: Pathogenesis and Clinical Findings
Continued Innate Immunity
 • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
Natural Killer Cells ... • Humoral: (B cell ... : (T cell response ... activity #Inflammatory ... #Inflammation #pathophysiology
Humoral Immunity - Pathogenesis and Clinical Findings
Antigens (Ag) are produced from pathogens (bacteria, viruses, fungi, parasites)
cells and activate ... B cellsT cell-independent ... neutralizing them - Activate ... Complement: Abs activate ... Humoral #Immunity #pathophysiology
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
tissues where they activate ... activate Th1/cytotoxic ... T cells. ... T-cells recruit ... allergy #table #classification
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Differential Diagnosis Algorithm ... as common - T ... Lymphoproliferative #Disorders #Classification ... #pathophysiology ... #differential #algorithm
Erythroderma - Diagnostic Algorithm. Pathophysiology: 1) Extensive cutaneous capillary dilation, results in widespread exfoliation of the
Erythroderma - Diagnostic Algorithm ... Pathophysiology: ... germinative skin cells ... 4) Skin-homing T-cells ... Erythroderma #Nikolsky #Algorithm
Anticonvulsants as Mood Stabilizers: Mechanism and Side-effect
Examples: Valproate, Carbamazepine, Lamotrigine
 • Mild anticholinergic effect -> Drowsiness
Benign Rash • T-cell ... of dopaminergic activity ... #SideEffects #Pathophysiology
Antiarrhythmics - Vaughan Williams Classification:
CLASS 1 - Sodium Channel Blockers:
 • MOA: Block fast Na+ channels
Vaughan Williams Classification ... node and AV node activity ... ++ influx into cells ... #Pharmacology #Classification ... #Classes #pathophysiology