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management differential neurology rheumatology cns demyelinating diseases erythematosus hematology hemeonc hemophagocytic histiocytosis hlh hypertension igg4 langerhans lch lupus lymphohistiocytosis myelitis
Clinical Classification of Pulmonary Hypertension 1. Pulmonary arterial hypertension from pulmonary vasculopathy Idiopathic pulmonary arterial hypertension Heritable gene mutations
Clinical Classification ... protein receptor type ... pulmonary Langerhans cell ... #Diagnosis #Differential ... #Causes
IGG-4 RELATED DISEASE WHAT? • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
- Organ dysfunction ... PATHOPHYSIOLOGY ... • Key Features ... • Pancreas: Type ... complement • Classification
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Sarcoidosis - Diagnosis ... survival is 93-95% Pathophysiology ... : 1) T-cell dysfunction ... and increased B-cell ... failure Clinical Features
SEPSIS AND SEPTIC SHOCK DEFINITION AND PATHOPHYSIOLOGY • Sepsis: Life-threatening organ dysfunction due to a dysregulated host
DEFINITION AND PATHOPHYSIOLOGY ... • Pathophysiology ... risk death), T-cell ... mental status DIAGNOSIS ... Septic #Shock #Diagnosis
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
monophasic Pathophysiology ... Alterations: - Sensory features ... bouts of HTN Diagnostic ... Pleocytosis > 100 cells ... • Infectious causes
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Skin Disease Classification ... Differential Diagnosis ... Kikuchi disease • Type-I ... mild cognitive dysfunction ... : • Chronic B-cell
Langerhans Cell Histiocytosis (LCH) Granulomatous Lesions comprising langerin-positive histiocytes and an inflammatory infiltrate can arise in virtually
, a type of dendritic ... : LCH exhibits features ... • Endocrine Dysfunction ... DIAGNOSIS • Imaging ... Histiocytosis #Diagnosis
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
cytopenias and organ dysfunction ... hyperinflammatory syndrome caused ... Persistent fever, organ dysfunction ... Types of HLH • ... Pathophysiology
DEMYELINATING DISEASES OF THE CENTRAL NERVOUS SYSTEM What Are Demyelinating Diseases? • Conditions that damage myelin, the protective
Oligoclonal bands, cell ... • Clinical Types ... • Features: Bilateral ... autoimmune/infectious causes ... bladder/bowel dysfunction
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