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diagnosis differential hematology management bandemia causes cbc coronavirus covid19 guide hemophagocytic hlh immunecompromised immunocompromised lymphohistiocytosis neutrophil perioperative preop preoperative protocol
SEPSIS AND SEPTIC SHOCK DEFINITION AND PATHOPHYSIOLOGY • Sepsis: Life-threatening organ dysfunction due to a dysregulated host
DEFINITION AND PATHOPHYSIOLOGY ... Life-threatening organ dysfunction ... cellular/metabolic dysfunction ... • Pathophysiology ... • Symptoms: Fever
UCSF COVID-19 Adult Clinical Evaluation Guide - Updated April 10 2020 Clinical Presentation • Fever: hospitalized pts but
Adult Clinical Evaluation ... Presentation • Fever ... myocarditis • ENT: Taste ... UCSF #COVID19 #Evaluation ... Guide #Diagnosis #Algorithm
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... • Clinical: fever ... , Hb), Hepatic dysfunction ... inhibitors under evaluation
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
tachycardia or fever ... hypotension or septic shock ... count on initial evaluation ... CBC #hematology #pathophysiology
Preoperative Risk Evaluation Major Pre-Op Questions: 1. Does the patient have any modifiable risk factors that could be
Preoperative Risk Evaluation ... or family - Ever ... event, follow ACC algorithm ... with valvular dysfunction ... or LV dysfunction
Causes of Fever in the Immunocompromised Host - Differential Diagnosis Algorithm Structural Defect - Asplenia/HypospIenism • Bacteremia/Septic
Causes of Fever ... Differential Diagnosis Algorithm ... Bacteremia/Septic Shock ... or Neutrophil Dysfunction ... Infection #Fever
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