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Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Idiosyncratic Drug-induced ... symptoms of liver disease ... #DILI #Drug #induced ... #Management #gastroenterology
Gastrointestinal Evaluation of Iron Deficiency Anemia
In patients with anemia, diagnose iron deficiency if:
 • Ferritin <
patients with anemia, diagnose ... disease with serology ... change medical management ... Evaluation #workup #diagnosis ... #gastroenterology
Acquired von Willebrand Syndrome - Diagnosis and Management
 • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
Willebrand Syndrome - Diagnosis ... and Management ... thrombocythemia), Autoimmune disease ... • Shear stress-induced ... #hematology #differential
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Initial screening test ... with more severe disease ... #SLE #Summary #diagnosis ... #rheumatology # ... management
Our approach to the diagnosis and initial management of patients with suspected HIT. Our approach is
and initial management ... HIT laboratory tests ... #Diagnosis #Management ... #Hematology #HIT ... #Heparin #Induced
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
Positive pathergy test ... is a skin prick test ... Giant retinal tears ... #management #signs ... #symptoms #rheumatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
underlying liver disease ... Hepatitis (AAH) Drug-Induced ... Hepatitis Procedures Management ... Cirrhosis #Hepatology #gastroenterology ... #management #diagnosis
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook

Presentation: 
 • Plts ↓50% (nadir
Heparin Induced ... approach for post-test ... : Confirmatory test ... #HIT #Heparin #Induced ... #Hematology #HemeOnc
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Presentation - Cold-Induced ... Acrocyanosis (Cold-induced ... Test: Donath-Landsteiner ... test #cold # ... hemolytic #anemia #hematology
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
of 37°C to the near-freezing ... Cryofibrinogenemia Diagnosis ... syndrome • Warfarin-induced ... Cryofibrinogenemia #diagnosis ... #rheumatology #