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Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Glomerulonephritis, arthritis, obstructive ... pulmonary disease ... - GI tract: abdominal ... well as inner ear ... differential #diagnosis #rheumatology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
pain and GN Anti-GBM ... Glomerulonephritis, arthritis, obstructive ... pulmonary disease ... disease #Vasculitis ... Differential #Diagnosis #Rheumatology
Highlighted Conditions With Arteritis or Periarteritis of the Coronaries
Takayasu's arteritis:
 - Onset < 40 yrs
 -
nodules, livedo - Abdominal ... multiplex ANCA vasculitis ... sinusitis - pulmonary ... Leukocytoclastic vasculitis ... Ulceration GI tract - Ocular
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
, small-vessel vasculitis ... Giant retinal tears ... • Nonsurgical abdominal ... pain: Glucocorticoids ... signs #symptoms #rheumatology
Diagnosis of IgA Vasculitis (Henoch-Schönlein Purpura) - French Vasculitis Study Group 

1) Suggestive clinical manifestations
Diagnosis of IgA Vasculitis ... of patients : abdominal ... pain +++, potential ... - Systemic disease ... HSP #Diagnosis #Rheumatology
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Butterfly rash, Vasculitis ... valve lesions Abdominal ... pain (20%) Renal ... disease (30%): ... symptoms #diagnosis #rheumatology
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
malignancies, vasculitis ... thrombophlebitis, pulmonary ... emboli, and ocular ... Cryofibrinogenemia #diagnosis #rheumatology ... #hematology
Extra-articular and Other Conditions Associated with Joint Pain

Eyes
  • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Associated with Joint Pain ... Pulmonary ... , Vasculitis (e.g ... Inflammation of ear ... differential #diagnosis #rheumatology
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
gland) biopsy • Ocular ... : • 10%-15% Pulmonary ... Nephrogenic DI Hematologic ... Symptomatic: artificial tears ... Sjogrens #Syndrome #Rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Erythematous, macular ... ANCA-associated vasculitis ... Non-autoimmune rheumatologic ... Arthritis: • Joint pain ... Erythematosus #Diagnosis #Rheumatology