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differential management dermatology fuo activation anemia blood chronic classification dengue disorders elevatedmcv fatigue hemeonc hemophagocytic hlh infectiousdiseases lymphohistiocytosis macrocytic macrocytosis
Fever of Unknown Origin (FUO) - Further Workup • CNS symptoms? Get an LP and imaging
FUO) - Further Workup ... Returning Traveler’ algorithm ... Test for the respective ... values supporting hematologic ... #diagnosis
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... and Workup History ... , ANA (e.g., SLE ... #Causes #Workup ... #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... - Differential Diagnosis ... Algorithm Normal ... #Algorithm #Causes ... #Hematology
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Causes of Fatigue ... Renal Failure • Liver ... Neoplastic / Hematologic ... Infectious • Endocarditis ... #Algorithm #causes
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Red Flags: • Fever ... Schonlein Purpura - Endocarditis ... deficiency Work ... Fecal occult blood test ... #Algorithm #Causes
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
halt nail growth (e.g ... • Bacterial endocarditis ... discoloration) • Liver ... #Differential #Diagnosis ... #Algorithm #causes
Endocarditis Summary Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV substance use • IV catheter • Recent
night sweats, fever ... Septic Emboli Cause ... -> TEE • Duke Criteria ... ↑ ESR, CRP • EKG ... #cardiology
Possible Algorithm for Workup of Fever of Unknown Origin (FUO) Tier 1 Workup: • CBC, comprehensive metabolic
for Workup of Fever ... release assay (e.g ... • Additional tests ... marrow, Lymph node, Liver ... #diagnosis
Modified dengue severity classification, PAHO/WHO Dengue without warning signs - DNWS: • Person who lives or has
days and presents fever ... the following criteria ... positive tourniquet test ... organs #dengue #fever ... classification #diagnosis
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
thrombocytopenia • Liver ... function tests ... Histopathologic criteria ... Activation #Syndrome #Diagnosis ... #Management #Hematology
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