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diagnosis differential algorithm liver oncology lfts management transaminitis aplastic causes chemistry cll common cvid erythematosus gap globulin hypogammaglobulinemia immunodeficiency immunology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver Injury ... cirrhosis, Portal Vein Thrombosis ... 5-10x normal - Chronic ... Patterns #Liver #Injury ... #hepatology #LFTs
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... for workup, including ... hemolysis, deficiency anemia ... • Infections: Chronic ... Diagnosis #Algorithm #hematology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
vein: Budd-chiari syndrome ... : Shock liver, Thrombosis ... > 2 • NASH, Chronic ... : > 3 • Chronic ... diagnosis #algorithm #hepatology
Causes of Seizures - Differential Diagnosis Algorithm Unprovoked - Epilepsy: • Focal: Simple, Complex • Generalized: Absence,
Cerebral venous thrombosis ... vasoconstriction syndrome ... Traumatic brain injury ... Cerebral Hypoxia, Uremia ... Algorithm #Causes #neurology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Marrow (Toxic injury ... Constitutional Syndromes ... Constitutional Syndromes ... : - Hepatitis ... #oncology #hematology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
> 2 • NASH, Chronic ... viral hepatitis ... : > 3 • Chronic ... • Gilbert's syndrome ... #differential #Hepatology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Autoimmunity • Chronic ... Liver diseases and hepatitis ... autoimmune hemolytic anemia ... : • Nephrotic syndrome ... hypogammaglobulinemia #immunology #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... • Neutropenia, anemia ... • Richter’s Syndrome ... Leukemia #diagnosis #workup ... #oncology #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... • Aplastic Anemia ... Marrow Failure • Chronic ... Workup: • Complete ... #diagnosis #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Malignancy (e.g. hematologic ... Noninfectious hepatitis ... Hematologic: ... lymphopenia, low PLT • Anemia ... with Lupus: • Chronic
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