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diagnosis management differential hematology hlh lymphohistiocytosis infectiousdiseases opportunistic activation aids bee capsulatum cerebritis erythematosus fungal hemeonc histoplasma histoplasmosis hiv idsa
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Hemophagocytic Lymphohistiocytosis ... • Autoimmune diseases ... Adult-onset Still disease ... Treatment: • ... #summary #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Treatment Primary HLH: - HLH-94 Protocol • Dexamethasone
Hemophagocytic Lymphohistiocytosis ... (depending on CNS ... associated with infection ... or autoimmune disease ... #management #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
A subset of hemophagocytic ... nervous system (CNS ... SLE], AOSD) • Infection ... Treatment: • Corticosteroids ... #Rheumatology
CNS Infection in HIV / AIDS - Differential Diagnosis Framework Principles of HIV-Associated CNS Opportunistic Infections: •
CNS Infection in ... Antimicrobial treatment ... status, and focal neurologic ... Demyelinating disease ... caused by the JC
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... Cerebrovascular Disease ... autoantibodies that will cause ... Erythematosus #SLE #CNS ... #neurology #rheumatology
BEE Syndromes - Non-inflammatory Causes Immune-mediated conditions affecting the Brain, Eye, and Ear Visual or auditory symptoms in
Non-inflammatory Causes ... nervous system (CNS ... diagnosis and treatment ... • Lyme disease ... BEE #Syndromes #neurology
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
pulmonary symptoms • Rheumatologic ... extrapulmonary disease ... or meningitic disease ... especially the CNS ... MC: CNS CSF: •
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
that results in CNS ... super-antigen mediated disease ... MCTD - Bechet disease ... Transverse Myelitis Treatment ... diagnosis #management #neurology
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
Management Summary Causes ... Statins - ETOH - Infection ... disease 2. ... per day until stable ... #treatment #nephrology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
affects the skin, neurologic ... cognitive impairment, neurologic ... tract, and often causes ... chorioretinitis, CNS ... Differential #Diagnosis #Rheumatology
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