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Common Etiologies of Cirrhosis

Inflammation

 - Hepatitis B (15 percent)

 - Hepatitis C (47 percent)

 - Schistosomiasis
Inflammation - Hepatitis ... 15 percent) - Hepatitis ... #Diagnosis #Differential ... #Hepatology #Cirrhosis ... #Causes
Hepatomegaly - Differential Diagnosis Algorithm
Malignant
 • Primary Carcinoma
 • Metastases
 • Lymphoma
 • Leukemia
 • Polycythemia
Hepatomegaly - Differential ... Hemochromatosis • Wilson's Disease ... Primary Biliary Cirrhosis ... Diagnosis #Algorithm #Causes ... #Hepatology
Causes of Severe Acute Liver Injury
 - Ichemic hepatitis
 - Acute biliary obstruction
 - Drug-Induced liver
Causes of Severe ... - Wilson disease ... Severe #Acute #Causes ... #Differential # ... Hepatology #Diagnosis
Ascites - Differential Diagnosis
Chronic liver disease (cirrhosis or chronic hepatitis) - 80%
Underlying malignancy - 10%
Congestive heart
Ascites - Differential ... Chronic liver disease ... (cirrhosis or chronic ... hepatitis) - 80% ... #Diagnosis #hepatology
Portal Hypertension - Differential Diagnosis
Portal Pressure = the pressure difference between the pressure in the portal
Hypertension - Differential ... /acute hepatitis ... • Infiltrative diseases ... Veno-occlusive disease ... #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
those with CLD (± cirrhosis ... months without treatment ... underlying liver disease ... (DILI) Viral Hepatitis ... #Hepatology #gastroenterology
Hepatobiliary Manifestations of Sickle Cell Disease
Acute sickle cell hepatic crisis:
 • Fever, acute onset RUQ pain,
of Sickle Cell Disease ... Supportive with treatment ... #SickleCell #Disease ... Hepatobiliary #hepatology ... #hepatitis #differential
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
• Cholestatic disease ... • Alcoholic hepatitis ... Infiltrative • Cirrhosis ... Others #LFTs #Hepatology ... Diagnosis #Algorithm #Causes
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Causes of Acute ... Liver Injury - Differential ... Liver #Injury #Differential ... #Diagnosis #Causes ... Acute #algorithm #hepatology
Causes of Splenomegaly - Differential Diagnosis Algorithm
Infectious
 • Bacterial
 • Viral (EBV)
 • Parasitic
 • Fungal
Congestive
Causes of Splenomegaly ... - Differential ... Congestive • Cirrhosis ... Spleen #Enlarged #Differential ... #Hematology