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diagnosis hematology management oncology algorithm differential hlh lymphohistiocytosis activation chronic cll erythematosus gap globulin hemeonc hodgkins leukemia lupus lymphocytic lymphoma
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
for workup, including ... hemolysis, deficiency anemia ... Rebound effect from treatment ... Malignancy: Metastatic cancer ... Vasculitides, IBD, Celiac disease
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Hemophagocytic Lymphohistiocytosis ... B-LNH), solid cancers ... • Autoimmune diseases ... Unknown cause Treatment ... #summary #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
A subset of hemophagocytic ... SLE], AOSD) • Infection ... with leukopenia, anemia ... Treatment: • Corticosteroids ... #Rheumatology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
History of EBV infection ... Weight loss • Anemia ... Hodgkin Lymphoma Workup ... number of sites of disease ... Hodgkin Lymphoma Treatment
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Leukemia - Summary Cancer ... weeks without infection ... cells can indicate disease ... • Neutropenia, anemia ... microglobulin Treatment
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: ... Non-autoimmune rheumatologic ... fibromyalgia) • Infections ... lymphopenia, low PLT • Anemia ... • Cervical cancer
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... petechiae) • Frequent infections ... Myeloproliferative Disease ... • Parvovirus infection ... Workup: • Complete
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
Hemophagocytic Lymphohistiocytosis ... it is often a cancer ... ▪ Autoimmune diseases ... - Cytopenias (anemia ... #HLH #Hemophagocytic
Myelodysplastic syndromes current treatment algorithm 2018. From Blood Cancer Journal, Published 24 May 2018 Myelodysplastic syndromes (MDS) are
syndromes current treatment ... influence outcomes and treatment ... tolerate anemia ... may result in an infection ... #algorithm #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... • Heavy chain disease ... Include: • Viral infections ... ovarian tumors, lung cancers ... Thalassemia, Sickle cell anemia
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