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diagnosis hematology differential leukemia management algorithm classification cll approach common cvid diffuse hemeonc hodgkins hypogammaglobulinemia immunodeficiency immunology lad lymphadenopathy lymphoma
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic ... • Peripheral smear ... 5) Symptoms of anemia ... marrow failure with anemia ... #oncology #hematology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... Age > 50 • Chronic ... Lymphocytic Leukemia ... Diagnosis #Algorithm #Causes ... #Hematology #Oncology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Normochromic RBCs on Smear ... • Chronic Bleed ... • Anemia of Chronic ... Diagnosis #Algorithm #Causes ... #Hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... • Peripheral smear ... • Neutropenia, anemia ... diagnosis #workup #oncology ... #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
peripheral blood smear ... -> AML: Blast crises ... - infiltrates (anemia ... • Peripheral smear ... #Oncology #Diagnosis
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
of chronic inflammation ... of chronic kidney ... of chronic inflammation ... differential #diagnosis #causes ... #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Peripheral Smear ... Marrow Failure • Chronic ... Peripheral blood smear ... Syndromes #diagnosis #hematology ... #oncology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Autoimmunity • Chronic ... Granulomatous lymphocytic ... autoimmune hemolytic anemia ... DDX - Other causes ... Malignancies • Chronic
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Weight loss • Anemia ... Immune hemolytic anemia ... HL (MCHL) - Lymphocyte ... classification #hematology ... #oncology #management
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
musculoskeletal systems • Kidneys ... elevated protein, lymphocytic ... Eosinophilia, asthma, chronic ... tract, and often causes ... Differential #Diagnosis #Rheumatology
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