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neurology druginduced sle syndrome ascorbicacid cerebritis coagulation comparison dic differential dil disseminated erythematosus fungal hematology infections infectiousdiseases intravascular mycoses myelitis
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... Disease, PRES Pathophysiology ... autoantibodies that will cause ... #neurology #rheumatology ... #management #treatment
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
protein C and S Pathophysiology ... Thromboembolism (7%) • CNS ... #Coagulation #diagnosis ... #causes #treatment ... #management #hematology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
is rare in DIL, SCLE-DIL ... life-threatening • Treatment ... Usual therapeutic management ... comparison #table #rheumatology ... #diagnosis #management
Stiff Person Syndrome (SPS) - Diagnosis and Management Summary Epidemiology: • Prevalence: 1-2 cases per million -
and Management ... Prevalence: 1-2 cases ... Person Syndrome Pathophysiology ... Person Syndrome Treatment ... #Management #treatment
Scurvy (Vitamin C Deficiency) - Diagnosis and Management Vitamin C is required for hydroxylation of proline residues
and Management ... nonimmune hemolysis MSK ... • Weakness • Muscle ... , or any other cause ... vasculitis Treatment
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... phenomenon (16%) MSK ... Adenocarcinoma Treatment ... Sjogrens #Syndrome #Rheumatology ... #Diagnosis #Management
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
pulmonary symptoms • Rheumatologic ... fever, chills, muscle ... MC: CNS CSF: • ... Aspergillosis Pathophysiology ... #Management #Infections
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
monophasic Pathophysiology ... that results in CNS ... • Infectious causes ... Transverse Myelitis Treatment ... #management #neurology
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
is rare in DIL, SCLE-DIL ... Discontinuation of causal ... #DIL #rheumatology ... #diagnosis #treatment ... #management
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
including systemic lupus ... Hepatic cirrhosis - TTP ... cell lymphoma Pathophysiology ... Hypoalbuminemia Treatment ... #management #rheumatology
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