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Acquired von Willebrand Syndrome - Diagnosis and Management • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
Willebrand Syndrome - Diagnosis ... Autoantibodies to vWF ... Autoimmune disease • vWF ... vonWillebrand #Syndrome #Diagnosis
Bleeding manifestations Petechiae are small, flat, red, discrete areas of skin bleeding that are typically <2
Diagnosis VWF ... (Quantity of VWF ... considered to be low) VWF ... of this plasma VWF ... (differentiate VWD
Von Willebrand Disease Classification Type 1 (Accounts for ~3/4 of cases): • Defect: Quantitative defect (i.e. not
i.e. not enough VWF ... dysfunctional VWF ... total absence of vWF ... Classification #Types #diagnosis
Inherited Qualitative Platelet Defects Bernard-Soulier Syndrome • Defect of adhesion due to a lack of GP Ib/IX/V
of GP Ib/IX/V [vWF ... α-granules (contains vWF ... #differential #diagnosis
Platelet disorders and Aggregometry Glanzmann Thrombasthenia • Defective aggregation to all agonists except ristocetin • Normal platelet,
also be seen in vWD ... differentiate vWD ... BS by measuring vWF ... #differential #diagnosis
Coagulation cascade and anticoagulants Satyendra Dhar MD, @DharSaty #coagulation #coumadin #heparin #warfarin #apaxiban #pradaxa #xarelto #DOAC #vWF
xarelto #DOAC #vWF
Approach to Von Willebrand disease (VWD) By Matthew Ho, MD PhD @MatthewHoMD #VWD #Von #Willebrand #VonWillebrand #disease #hematology
Willebrand disease (VWD ... MatthewHoMD #VWD ... hematology #algorithm #diagnosis
Tachycardia - Differential Diagnosis Framework Narrow-Complex: • Regular: Sinus Tachycardia, Junctional Tachycardia, Atrial Tachycardia, Atrial Flutter, AVRT
- Differential Diagnosis ... (ie Torsades, VF ... #Differential #Diagnosis
Hemoptysis - Differential Diagnosis Framework Massive Hemoptysis: >150-300 mL in 24h Airway disease: • Bronchitis, Bronchiectasis, Malignancy
- Differential Diagnosis ... Coagulopathy: DIC, vWD ... #Differential #Diagnosis
2021 ACR/VF Guidelines for Management of Giant Cell Arteritis (GCA) #GiantCell #Arteritis #GCA #ACR2021 #Management #rheumatology #algorithm
2021 ACR/VF Guidelines
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