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differential injury transaminitis causes management aclf autoimmune chemistry chronic cirrhosis druginduced failure function gastroenterology interpretation liverenzymes patterns rvalue tests
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - ... Differential Diagnosis ... Hepatopathy • Acute ... (>1000): • DILI ... #hepatology #transaminitis
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... months without treatment ... Liver Injury (DILI ... Failure #Cirrhosis #Hepatology ... gastroenterology #management #diagnosis
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Algorithm DILI ... non-essential drug/HDS treatments ... dechallenge • Acute ... #Diagnosis #Algorithm ... #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
> 20x normal - Acute ... cirrhosis, Portal Vein ... #Injury #hepatology ... #LFTs #transaminitis ... #differential #diagnosis
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Algorithm Vascular ... • Hepatic vein: ... • Iatrogenic: DILI ... #algorithm #hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... Diagnosis Hepatocellular ... Vasculature • Hepatic Vein ... #Differential #Diagnosis ... #algorithm #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... viral hepatitis ... #chemistry #diagnosis ... #differential #Hepatology ... transaminitis #LFTs
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... • Drugs • AIH ... • Alcoholic hepatitis ... • Others #LFTs ... #Hepatology #LiverEnzymes
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
subclinical disease to acute ... , AIH diagnosis ... regarding need for treatment ... #AIH #Diagnosis ... #Management #Hepatology
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