11 results
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... Triggering factor (infection ... →Activation of CD8 ... Still disease, Infection ... treatment #summary #rheumatology
Bandemia Overview

Normal: < 1%
Clinically significant: > 10%

Band neutrophils are slightly less mature than segmented neutrophils and
predictive of a serious infection ... overlook severe infections ... superior indicator of infection ... neutrophil #WBC #CBC ... #hematology #pathophysiology
Nontuberculous Mycobacteria (NTM) Infections 

Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
Mycobacteria (NTM) Infections ... Found In: • Water ... • Nodular or ... • Municipal water ... Advanced HIV (CD4
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
procedures - Infection ... decreased PLT count: CBC ... (CVID, WAS), (neurologic ... Causes #Workup #hematology
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
monophasic Pathophysiology ... Direct microbial infection ... Hyperreflexia develops later ... be ordered • Infectious ... diagnosis #management #neurology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
to exclude are infections ... affects the skin, neurologic ... cognitive impairment, neurologic ... Cogan syndrome: Ocular ... Differential #Diagnosis #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
ulcers, cutaneous, ocular ... Syndrome: - Ocular ... to exclude are infections ... Lab Tests: • CBC ... differential #diagnosis #rheumatology
Lung Abscess - Diagnosis and Management Summary

Lung Abscess Etiology:
 • Necrosis of lung parenchyma by a
polymicrobial infection ... Lung Abscess Pathophysiology ... necrosis (7-14 days later ... Diagnosis: • CBC
HIV-Associated Neurocognitive Disorder (HAND)

Definition:
HIV-Associated Neurocognitive disorders categories:
• Asymptomatic neurocognitive impairment
• Mild neurocognitive impairment
• HIV dementia

Pathophysiology:
HIV frequently
HIV dementia Pathophysiology ... early stages of infection ... Findings: • Rule out infectious ... HIV and with low CD4 ... dementia #AIDS #Neurology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Erythematous, macular ... Non-autoimmune rheumatologic ... fibromyalgia) • Infections ... titers > 1:80 • CBC ... Erythematosus #Diagnosis #Rheumatology