Algorithm for Diagnosis and Management of Resistant Hypertension in CKD
Pseudoresistant Hypertension - Reduce barriers to adherence:
• Prescribe generics
• Use once-daily medications
• Combination formulations
• Patient education
• Assess for adverse effects
Initiate Lifestyle Modifications
• Low sodium diet mg/d)
• Address obesity
• Increase physical activity
• DASH diet and reduce alcohol intake
• Evaluate for and treat OSA
• Discontinue BP-raising medications
Resistant Hypertension
1. Evaluate for CKD
2. Screen for primary aldosteronism
3. Consider other causes of 2° HTN
eGFR < 30 mL/min/1.73 m2:
1. Add loop diuretic to existing thiazide
2. Titrate to "dry weight"
3. Hold if under dry weight
→Add mineralocorticoid antagonist
→Refer to HTN specialist
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