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Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased WBCs
 - Decreased/NormaI
Normal/lncreased WBCs ... Macrocytes, Normal RBCs ... Polychromatic Macrocytes, RBC ... Spherocytes, RBC ... ) - Abnormal RBCs
Urine Microscopy and Casts - Image Atlas Key

- Squamous Epithelial Casts
- Transitional Epithelial Cells
- Renal Tubular
Hyaline Cast - WBCs ... - Monomorphic RBCs ... - Dysmorphic RBCs ... - WBC Cast - RBC
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
/ Normochromic RBCs ... TIBC, Hypochromic RBCs ... Decreased RBC ... Thalassemia • RBC ... Disorder • RBC
Hematuria Workup and Diagnosis Algorithm
 • Confirm hematuria → Urinalysis >3 RBCs/HPF, exclude mimics, repeat testing
Urinalysis >3 RBCs ... of UTI, urine WBCs ... (proteinuria, RBC ... casts, dysmorphic RBCs
The differential diagnosis for an elevated MCHC (mean corpuscular hemoglobin concentration) includes:

Conditions with Abnormal RBCs:
 •
with Abnormal RBCs ... : • Abnormal RBC ... Xerocytosis • RBC
Nephritic vs Nephrotic Syndrome

Step 1: If the patient has hematuria and/or proteinuria, think about nephrotic/nephritic syndromes.
Step
glomerular hematuria (RBC ... or dysmorphic RBCs
Red cell autoagglutination is the process whereby red cells clump together forming aggregates. This is seen
red blood cells (RBCs ... serum due to the RBCs ... Smear #Microscopy #RBC
Red cell autoagglutination is the process whereby red cells clump together forming aggregates. This is seen
red blood cells (RBCs ... serum due to the RBCs ... Smear #Microscopy #RBC
Pathophysiology of Hemolytic Anemia
 - Defects in RBC internal contents (thalassemia, hemoglobinopathies, and metabolic defects)
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- Defects in RBC ... - Defects in RBC ... Defects in the RBC's
Anemia Diagnostic Algorithm

Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
(MCV): Average RBC ... among size of RBCs ... wide range of RBC ... reticulocytes (immature RBCs