Chemotherapy Toxicity Bear Mnemonic - Cumulatively Toxic Drugs and their Rescues • Asparagine: neurotoxicity • Cisplatin: ototoxic/nephrotoxic; Tx: Amifostine • Vincristine/Vinblastine: "Christ my nerves, Blast my bones" - Vincristine = peripheral neuropathy, Vinblastine = myelosuppression • Bleomycin: pulmonary fibrosis • Doxorubicin: cardiotoxic; Tx; Dexrozoxane (for cardiotoxicity), Dimethyl-sulphoxide (for ROS ulcers) • Cyclophosphamide: Acrolein = nephro/bladder toxic (Tx: Mesna); also SIADH effects (Tx: Demeclocycline) • Methotrexate: nephrotoxic (Tx: Leucovorin), myelosuppression (Tx: Filgrastim) Salim R. Rezaie, MD @srrezaie #Chemotherapy #Toxicity #Bear #Mnemonic #Drugs #pharmacology #oncology #SideEffects #Adverse
