Factor VIII synthesis - Normal, Haemophilia A and Von Willebrand Disease Normal - vWF carrier protein protects VIII:C from degradation. It is released by activated thrombin. Haemophilia A - Defective synthesis of VIII:C Von Willebrand Disease - Rapid degradation of VIII:C in the absence of vWF. #FactorVIII #synthesis #HaemophiliaA #VonWillebrand #Disease #Pathphysiology
