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diagnosis management cardiology differential algorithm ekg clinical ecg electrocardiogram pathophysiology causes treatment checklist pharmacology criticalcare nephrology pediatrics classification neurology peds
ANCA-Associated Vasculitis A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
associated with PR3 ... involvement - PR3 ... 75-90%, rarely PR3 ... disease - MPO>PR3 ... + almost 100%, PR3
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
polyangiitis - MPO>PR3 ... polyangiitis - PR3 ... involvement - PR3 ... Churg-Strauss) - MPO>PR3 ... disease - MPO>PR3
Frequency of ANCA Positivity in Different Conditions ANCA-Associated Vasculitis • GPA - PR3-ANCA 75%, MPO-ANCA 20%, 5%
Vasculitis • GPA - PR3 ... negative • MPA - PR3 ... negative • EGPA - PR3 ... positivity for MPO and PR3 ... sensitivity #MPO #PR3
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
proteinase 3 (PR3 ... in >90%, MPO > PR3 ... Granulomas - MPO > PR3 ... 80% (80-90% have PR3 ... proteinase 3 (PR3
ANCA Associated Vasculitis (AAV) - Auto-antibodies and Differential Diagnosis MPA → usually p-ANCA GPA → usually c-ANCA EGPA →
(MPO) C-ANCA (PR3
Causes of Hypercalcemia due to increased Vitamin D levels • The BIG 3:
granulomatous diseases: PR3
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Negative IF): • PR3
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
proteinase 3 (PR3 ... in > 30 / MPO > PR3 ... hemoptysis, MPO > PR3 ... 90 percent have PR3
Feedback Loop: Prolactin (PRL) • PRL levels exhibit diurnal, menstrual, and age-related variation • TRH has
Loop: Prolactin (PRL ... ) • PRL levels ... stimulatory effect on PRL ... secretion Prolactin (PRL ... #Prolactin #PRL
Hypertension in Pregnancy - Differential Diagnosis Algorithm Pre-existing Hypertension - Before Pregnancy OR <20 weeks gestational age
Diagnosis Algorithm Pre-existing ... Conditions • Pre-existing ... Hypertension with Pre-Eclampsia ... Hypertension with Pre-Eclampsia ... • Pre-Eclampsia
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