Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members with established disease) • aPTT is prolonged, but corrects with a mixing study (aPTT may be normal in mild cases) • PT/INR & von Willebrand factor antigen (vWF:Ag) are normal Individual factor activity levels (VIII, IX, +/- XI) are measured to: • Confirm the diagnosis • Establish hemophilia type (e.g. A vs. B) • Classify severity Treatment - Acute Bleeding: • For serious or moderate bleeding, treat with relevant factor immediately. • General targets: Serious: 100% factor activity Moderate: 50% factor activity Mild: Local therapy only is usually sufficient • Antifibrinolytic therapy can be a useful adjunct. Chronic Management: • If possible, patients should have multidisciplinary care coordinated by a hemophilia treatment center. Avoid meds that ↑ bleeding risk. • Encourage exercise, though safety assessment of athletic regimens should be individualized. • Prophylaxis with factors should be considered in those with severe disease, though the cost can be prohibitive. - Dr. Eric Strong @DrEricStrong - Strong Medicine https://www.youtube.com/c/EricsMedicalLectures/ #Hemophilia #Diagnosis #Management #treatment #hematology