Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf foreign pathogens and dead tissue • Complement System: opsonize pathogen (tag for destruction), promote inflammation • Natural Killer Cells: perforin-mediated wall breakdown (puncture holes), enzyme-mediated destruction Acquired Immunity Recruitment • Humoral: (B cell response) production of antibodies, activation of complement system • Cell-mediated: (T cell response) Increased helper cell and cytotoxic cell activity #Inflammatory #Cascade #Inflammation #pathophysiology #immunology