Dr. Gerald Diaz @GeraldMD
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Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief 🇵🇭 🇺🇸 - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG: https://www.instagram.com/grepmed/ | Twitter: https://twitter.com/grepmeded/
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diagnosis anemia hematology iron comparison defects extravascular fatigue fe hemolysis hyponatremia hypotonic inherited intravascular management nephrology nutrition physiologic platelet secondary
Causes of Iron Deficiency • Diet: ↓ Intake, e.g. vegan, Malnutrition, Polyphenol / tannins, ↓ Vitamin
Causes of Iron Deficiency ... Inflammation: IBD ... hepcidin) • Others: Hemolysis ... Iron metabolism disorders ... #Causes #differential
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
- Differential ... Diagnosis Algorithm ... DAT (-) → G6PD Deficiency ... #Anemia #Differential ... #causes
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... lymphoproliferative disorders ... G6PD deficiency) ... Extravascular #Causes ... #differential #
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential ... Diagnosis Algorithm ... Consider RBC membrane disorder ... #Anemia #Differential ... #Diagnosis #Algorithm
Causes of Iron Deficiency - Differential Diagnosis Algorithm • Blood loss: GI (cancer, ulcer, IBD), GU
Causes of Iron Deficiency ... - Differential ... Diagnosis Algorithm ... cancer, ulcer, IBD ... Intravascular hemolysis
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... - Differential ... specifically: iron deficiency ... , hemolysis, hemorrhage ... Chronic inflammatory disorders
Fatigue and IBD Algorithm • 40-50% patients have fatigue despite clinical remission • Risk factors: BMI,
Algorithm • 40- ... Receptor (sTfR) to differentiate ... restricted diet/deficiency ... /other causes • ... #Algorithm #diagnosis
Inherited Qualitative Platelet Defects Bernard-Soulier Syndrome • Defect of adhesion due to a lack of GP Ib/IX/V
to a lack of GP Ib ... MYH9-Related Disorder ... a storage pool deficiency ... Defects #comparison #table ... #differential #
Physiologic Approach to Hypotonic Hyponatremia The next time you have a case of hypotonic hyponatremia, give the
time you have a case ... normal volume-based algorithm ... mineralocorticoid deficiency ... #Hyponatremia #differential ... #diagnosis #table
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