Dr. Gerald Diaz @GeraldMD
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Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief πŸ‡΅πŸ‡­ πŸ‡ΊπŸ‡Έ - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG: https://www.instagram.com/grepmed/ | Twitter: https://twitter.com/grepmeded/
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Digoxin Pharmacology and Monitoring

 β€’ Digoxin’s half-life is 30-45 hours in healthy adults
 β€’ When monitoring
Digoxin Pharmacology ... and Monitoring ... #Pharmacology # ... Monitoring #toxicology ... #management #toxicity
Utilization of Antibiotics as Antidotes

Valproic Acid Toxicity:
Carbapenems 

Amatoxin Mushrooms: 
Polymyxin B, Penicillin, Cyclosporine

Infographic by Mike O'Brien
@MikeEMPharmD

#Antibiotics
Utilization of Antibiotics ... Valproic Acid Toxicity ... MikeEMPharmD #Antibiotics ... #Antidotes #Toxicology ... #Pharmacology
Therapeutic Drug Level Monitoring 
Carbamazepine - Sample immediately before next dose (trough) 
Clozapine - Sample immediately
Therapeutic Drug Level Monitoring ... at anytime if toxicity ... post dose (C2) Digoxin ... Therapeutic #Ranges #Toxicology ... #Pharmacology #
Antifungal Azoles - Antibiotics Class Overview

Mechanism:  inhibit ergosterol synthesis (important component of fungal cell membranes)
Antifungal Azoles - Antibiotics ... hepatic, main toxicity ... Isavuconazole(PO or IV) #Pharmacology ... #Antibiotics #Review
Flutycosine - Antibiotics Class Overview
 - 
Mechanism: 5-FC interferes with DNA and protein synthesis.  Only
Flutycosine - Antibiotics ... Thrombocytopenia) and Hepatic toxicity ... monitored to reduce toxicity ... #Pharmacology #Antibiotics ... #Review #Overview
Drug-Induced Prolonged QTc

QTc >500ms is an independent risk factor for developing Torsades des Pointes (TdP)
Drugs causing
Risperidone β€’ Antibiotics ... Prolonged #QTc #Toxicity ... #Toxicology #Pharmacology
Monobactam - Aztreonam - Antibiotics Class Overview

Spectrum: only has activity vs. aerobic gram negatives, no gram
- Aztreonam - Antibiotics ... combination with other antibiotics ... no significant toxicity ... #Pharmacology #Antibiotics ... #Review #Overview
Chloramphenicol - Antibiotics Class Overview

– 50S ribosomal inhibitor.   IV or PO (but PO form
Chloramphenicol - Antibiotics ... due to potential toxicity ... appropriate patients) - Toxicity ... #Pharmacology #Antibiotics ... #Review #Overview