Dr. Gerald Diaz @GeraldMD
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Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief πŸ‡΅πŸ‡­ πŸ‡ΊπŸ‡Έ - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG: https://www.instagram.com/grepmed/ | Twitter: https://twitter.com/grepmeded/
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High Anion Gap Metabolic Acidosis (HAGMA) - Differential Diagnosis - GOLDMARK

Glycols - ethylene and propylene glycol
Oxoproline
Gap Metabolic Acidosis ... L-lactate - produced during ... with short bowel syndrome ... Aspirin - salicylate ... toxicity causes
Salicylate Toxicity - Diagnosis and Management

Consider if:
1) Patient is hot and altered
2) You see tachypnea with
Salicylate Toxicity ... anion-gap metabolic acidosis ... Anion-Gap Metabolic Acidosis ... #Salicylate #Aspirin ... #Toxicity #Toxicology
Salicylate Toxicity - Diagnosis and Management

Clinical Findings
Pathophysiology
Workup
Treatment

By Stacy Marshall, MD

#Salicylate #Toxicity #Diagnosis #Management #Toxicology #Aspirin #Treatment
Salicylate Toxicity ... Diagnosis and Management ... Clinical Findings Pathophysiology ... #Salicylate #Toxicity ... #Toxicology #Aspirin
Salicylate Poisoning - Toxicology

Acute toxicity = vomiting, tachypnea, tinnitus, diaphoresis, and lethargy. This may progress to
Salicylate Poisoning - Toxicology ... and metabolic acidosis ... #Toxicology #Pharmacology ... #Diagnosis #Management ... #Aspirin
Metformin Associated Lactic Acidosis (MALA) 

Pathophysiology of MALA
 - Metformin interferes with the activity of the
Associated Lactic Acidosis ... (MALA) Pathophysiology ... LacticAcidosis #Toxicity ... #Toxicology #Diagnosis ... #Management
Propofol-Related Infusion Syndrome (PRIS)

Diagnosis is based on a constellation of clinical suspicion and biochemical signs including:
Propofol-Related Infusion Syndrome ... β€’ Metabolic acidosis ... PRIS #Diagnosis #Management ... #Pharmacology # ... Toxicity #Toxicology
Phases of Colchicine Toxicity
 - Early Phase (0-24h) 
 - Multi-organ failure Phase (1-7 days)
of Colchicine Toxicity ... Respiratory Distress Syndrome ... Metabolic: Metabolic acidosis ... #Toxicology #Phases ... #Pharmacology #
Pain, Agitation, and Delirium (PAD) in the ICU
Addressing the ICU Triad (PAD) can be accomplished through
Propofol infusion syndrome ... (PRIS) - acidosis ... glycol (solvent) toxicity ... No pharmacologic ... CriticalCare #diagnosis #management
Methotrexate Toxicology 

Intravenous leucovorin (folinic acid) treatment serves as a cofactor necessary for synthesis of thymidylate
Methotrexate Toxicology ... Leucovorin dosing ... evidence of marrow toxicity ... #Toxicity #Management ... #Pharmacology