Dr. Gerald Diaz @GeraldMD
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Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief πŸ‡΅πŸ‡­ πŸ‡ΊπŸ‡Έ - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG: https://www.instagram.com/grepmed/ | Twitter: https://twitter.com/grepmeded/
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NOAC / DOAC Pharmacology and Prescribing Cheat Sheet
Novel (or Direct) Oral Anti-Coagulants
 β€’ Rivaroxaban
 β€’ Apixaban
NOAC / DOAC Pharmacology ... #NOAC #DOAC #Pharmacology ... #Prescribing #hematology ... #management #Direct
Patient risk stratification algorithm for the treatment of cancer-associated thrombosis.

Currently, edoxaban and rivaroxaban are the only
anticoagulants (DOACs ... thrombosis; PE = pulmonary ... #Cancer #Algorithm ... Anticoagulation #Management ... #Hematology #Oncology
β–Ί
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓)
of cytochrome p450 CYP3A4 and P-glycoprotein.

DOACs are substrates
(DOAC interactions ... ) Cancer-treatment ... Chemotherapy #Oncology #Hematology ... #Interactions #Table ... #Pharmacology
DOAC Reversal
Emergency surgery or urgent procedure
Stop anticoagulant treatment; volume resuscitation and transfusion as needed
Antidotes:
 β€’ Apixaban,
DOAC Reversal Emergency ... not available #DOAC ... #Reversal #NOAC ... anticoagulant #hematology ... #management #pharmacology
Treatment algorithm for VTE in Malignancy

(A) Suggested treatment algorithm for symptomatic and incidental DVT or PE
thrombosis in cancer ... DOAC, direct oral ... #DOAC #VTE #Malignancy ... Anticoagulation #Management ... #Hematology #Oncology
Anticoagulant Bridging

 β€’ Switching from LMWH
 β€’ Switching from UFH
 β€’ Switching from DOAC to Warfarin
Switching from DOAC ... from Warfarin to DOAC ... anticoagulation #pharmacology ... #management #hematology
Acquired von Willebrand Syndrome - Diagnosis and Management
 β€’ Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
Diagnosis and Management ... adsorption onto cancer ... Syndrome #Diagnosis #Management ... #treatment #hematology ... #differential
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash Β± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
fraction < 20% Differential ... hemopathies, solid cancers ... hepatitis β€’ Pulmonary ... Disease #diagnosis #management ... #treatment #rheumatology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 β€’ Defect in fetal free fatty acid metabolism products β†’
infiltration) Differential ... Intrahepatic Cholestasis Management ... liver transplant center ... Liver #Pregnancy #hepatology ... obgyn #diagnosis #management
Liver Abscess and Mimics - Differential Diagnosis
Most Common: Polymicrobial, E Coli, Klebsiella, Strep/Enterococcus, Staph, Anaerobes
Infectious Differential:
Abscess and Mimics - Differential ... Anaerobes Infectious Differential ... HCC, Metastatic Cancer ... #Diagnosis #hepatology ... #management