The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Prader-Willi Syndrome: Pathogenesis and clinical findings
 • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Signs/Symptoms/Complications ... Incr Skeletal fractures ... Obesity -> Type 2 diabetes
Classification of Pelvic Ring Fractures: Mechanisms, Clinical Features and Complications
 • Anterior Posterior Compression (APC) -
of Pelvic Ring Fractures ... and Complications ... Sacral compression fracture ... Grade 2 - Rami fracture ... MSK #diagnosis #complications
Open Fractures: Mechanisms, Clinical Features and Complications
Gustilo-Anderson Classification:
 • Type I
   - Wound <
Open Fractures: ... Mechanisms, Clinical Features ... and Complications ... Classification #Open #Fractures ... #Diagnosis #Complications
Diabetic Nephropathy: Pathogenesis
 - Metabolic Pathway
 - Hemodynamic Pathway

#Diabetic #Nephropathy #Diabetes #pathophysiology
Diabetic Nephropathy ... Hemodynamic Pathway #Diabetic ... #Nephropathy #Diabetes
Femoral Head Fracture: Pathogenesis and clinical findings
 • Posterior hip dislocation -> Impaction force from femoral
Femoral Head Fracture ... Signs/Symptoms/Complications ... • Non-union of fracture ... #FemoralHead #Fractures
Stress Fracture: Pathogenesis and clinical findings
Abnormal biomechanics, Repetitive impact activities
=> Repetitive subthreshold mechanical loading
=> Bone strain
=>
Stress Fracture: ... => Microscopic fractures ... => Fracture propagation ... loading Stress Fracture
Diabetic Retinopathy: Pathogenesis and clinical findings

Mild Non-proliferative DR
 • Outpouchings of the weakened capillary walls or
Diabetic Retinopathy ... Neovascularization #Diabetic ... #Retinopathy #Diabetes ... ophthalmology #diagnosis #complications
Subtrochanteric Femur Fracture: Pathogenesis and clinical findings
 • Subtrochanteric region spans 5 cm distally from the
Subtrochanteric Femur Fracture ... low energy fall fractures ... Atypical femur fracture ... Subtrochanteric #Femur #Fractures
Clavicular Fracture: Pathogenesis and clinical findings

Group I (69%) - Middle third (mid-shaft)
Group II (29%) - Distal
Clavicular Fracture ... and the site of fracture ... with clavicle fractures ... #Clavicular #Fracture
Diabetic Foot: Pathogenesis and clinical findings
 • Polyol Pathway - Excess glucose enters Polyol pathway ->
Diabetic Foot: Pathogenesis ... neuropathy => Diabetic ... a person with diabetes ... pathophysiology #complications ... #Diabetes