The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology signs allergy complications definitions hypersensitivity reactions sle types avascularnecrosis erythematosus manifestations msk mucocutaneous musculoskeletal systemic
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
Immunological Target: Allergen ... Ex: Antibiotic allergies ... • Ex: Systemic Lupus ... #Types #Classification ... #Diagnosis #Definitions
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... Myopathy (Also caused ... #Systemic #Lupus ... pathophysiology #signs #symptoms ... #diagnosis
Hypersensitivity: Definitions • Type I - Production of lgE Abs that bind to harmless allergens and
leading to an allergic ... cell surfaces causes ... causes development ... #Types #Classification ... #Diagnosis #Definitions
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... Subacute cutaneous lupus ... hair follicles -> causes ... pathophysiology #diagnosis ... #signs #symptoms
Avascular Necrosis: Pathogenesis and Clinical Findings • Physical Trauma (esp. to the scaphoid bone with damage
) • Multiple causes ... therapy - Lupus ... pathophysiology #diagnosis ... #signs #symptoms
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