The Calgary Guide to Understanding Disease @TheCalgaryGuide
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psychiatry sideeffects pathophysiology antipsychotics mechanisms signs symptoms allergic definitions hypersensitivity inhibitors reactions types anticonvulsants differential firstgeneration mania manic mechanism moodstabilizers
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
Immunological Target: Allergen ... fever, Urticaria, Allergic ... #Allergic #Reactions ... #Types #Classification ... #Diagnosis #Definitions
Selective Serotonin Reuptake Inhibitors: Mechanisms and Side Effects • Serotonin Syndrome: - Autonomic Hyperactivity:
Selective Serotonin ... Side Effects • Serotonin ... Dizziness - Nausea ... Pathophysiology #Pharmacology ... SideEffects #Psychiatry #Diagnosis
Serotonin-Norepinephrine Reuptake Inhibitors(SNRIs): Mechanisms and Side Effects Withdrawal: Dizziness, Diarrhea, Insomnia, Nausea, Vomiting Serotonin Syndrome - Potentially Life
Serotonin-Norepinephrine ... , Vomiting Serotonin ... gain Incr NE: Nausea ... Pathophysiology #Pharmacology ... SideEffects #Psychiatry #Diagnosis
Hypersensitivity: Definitions • Type I - Production of lgE Abs that bind to harmless allergens and
leading to an allergic ... cell surfaces causes ... causes development ... #Types #Classification ... #Diagnosis #Definitions
Second Generation Antipsychotics: Mechanisms and Side Effects (Atypical Anti-Psychotics) - Examples: Clozapine, Olanzapine, Quetiapine, Risperidone, Zotepine, Paliperidone,
the brain • Serotonin ... the brain • Serotonin ... #SideEffects #pharmacology ... #diagnosis #psychiatry
Third Generation Antipsychotics: Mechanisms and Side Effects (Atypical Anti-Psychotics) Example: Aripiprazole Dopamine D2 Receptor Partial Agonist • Binds
under-stimulating receptors Serotonin ... #SideEffects #pharmacology ... #diagnosis #psychiatry
Anticonvulsants as Mood Stabilizers: Mechanism and Side-effect Examples: Valproate, Carbamazepine, Lamotrigine • Mild anticholinergic effect -> Drowsiness
constipation • Allergic ... Systemic effect -> Nausea ... Pathophysiology #Psychiatry #Pharmacology
First Generation Anti-Psychotics: Mechanisms and Side Effects Typical/Conventional Anti-Psychotics - Examples: Haloperidol, Chlorpromazine ACh M1 antagonist - Block
, and/or limbs caused ... #SideEffects #pharmacology ... #diagnosis #psychiatry
Medical Conditions Causing Mania or Mania-Like Episodes: Pathogenesis • Bipolar Disorder -> Combination of individual, genetic,
Decrased central serotonin ... Manic #Secondary #Causes ... #Differential #Diagnosis
Serotonin Syndrome: Pathogenesis and Clinical Findings Serotonin Syndrome: Variable combination of mental status changes, autonomic instability, and
Serotonin Syndrome ... Clinical Findings Serotonin ... ingestion and most cases ... make a clinical diagnosis ... Pathophysiology #Psychiatry #Diagnosis
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